Yes, but it’s very rare! Ligers are a cross between lions and tigers, and a few exist in the world, but this could never happen in the wild because they’re from different continents. They can breed though, there is now one liger liger in the world!
There are also examples of cross-breeding (known as ‘hybridisation’) happening in the wild. For example, around Cardiff the introduced Canada geese sometimes breed with the local Greylag geese. The offspring look very strange -exactly halfway in appearance between the 2 parents!